In recently years there has been a significantly growing interest in the algebraic spectral analysis of matrices in the form A = [ F B'; B -C ], and of their preconditioned versions P^{-1} A$, with the nonsingular matrix $P$ specifically chosen. In a variety of applications, this structure stems from the discretization of saddle point problems, so that the matrices F, B, C inherit relevant spectral properties. In this talk we review some of the results in the literature, with special emphasis on aspects that need be taken into account when designing structured preconditioners for a Krylov subspace system solver.